Background: This study aims to comprehensively characterize the dynamic succession of the salivary microbiome and metabolic reprogramming in type 2 diabetes mellitus (T2DM) patients across progressive stages of periodontitis (Stage I–IV) using an integrated multi-omics approach. We specifica","submission_date":"20260203"},{"title":"Bilophila wadsworthia inhibits lifestyle intervention response in Gestational Diabetes Mellitus via L-glutamine regulation","accession":"MTBLS13807","organisms":["Homo sapiens"],"description":"
Fecal samples were collected from 26 pregnant women with gestational diabetes mellitus (GDM) prior to and following a lifestyle intervention study, and subsequently analyzed using untargeted metabolomics.
","submission_date":"20260130"},{"title":"Acute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways","accession":"MTBLS10972","organisms":["Homo sapiens","blank"],"description":"Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ","submission_date":"20260402"},{"title":"Integrated Multi-omics Analysis Identifies Diagnostic Biomarkers for Acute Coronary Syndrome in Type 2 Diabetes Mellitus Patients","accession":"MTBLS14087","organisms":["Homo sapiens"],"description":"
Biomarkers for the early identification of acute coronary syndrome (ACS) risk remain inadequately investigated, particularly in patients with type 2 diabetes mellitus (T2DM), for whom timely clinical intervention may substantially enhance prognostic outcomes. The gut microbiota and serum metaboli","submission_date":"20260319"},{"title":"MTBLS12814: Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies","accession":"MTBLS12814","organisms":["Homo sapiens"],"description":"
Background
Regular physical activity is known to benefit health but the long-term effects of specific exercise training on human metabolism remain incompletely described. In this study, we comprehensively characterized the blood metabolomes of male athletes with distinct exercise-adapted me","submission_date":"20250804"},{"title":"Digital Phenomics and Dual-Fluid Metabolomics for Precision Stratification of Diabetic Kidney Disease: A Multicenter Cohort Study","accession":"MTBLS14007","organisms":["Homo sapiens","Homo sapiens"],"description":"
We conducted a prospective-retrospective two-center cohort study involving 364 participants. The Discovery Cohort (n=282) enrolled from two centers consisted of healthy controls (n=80), patients with type 2 diabetes mellitus (T2DM) without kidney disease (n=102), and patients with confirmed DKD (","submission_date":"20260309"},{"title":"Kidney protective effect of fermented celery polysaccharides and Eubacterium rectale in diabetic rats","accession":"MTBLS13958","organisms":["Rattus norvegicus"],"description":"
This study aimed to investigate the protective effects of non-fermented celery polysaccharides (NFCP), fermented celery polysaccharides (FCP), Eubacterium rectale (ER), and their combined intervention (ER+FCP) on Type 2 diabetes (T2D)-related kidney injury in a rat model, using untargeted urinary","submission_date":"20260302"},{"title":"Butyrate deficiency due to microbial dysbiosis promotes anxiety","accession":"MTBLS13477","organisms":["Mus musculus"],"description":"
for this association remains incompletely understood. Diabetes-associated genes have been implicated in the control of central nervous system (CNS) disorders. In the current study, we observed a significant downregulation of secretagogin (SCGN) across multiple organs in diabetic mouse models. Con","submission_date":"20251209"},{"title":"Zhaqu Compound Improves Glucose and Lipid Metabolism in T2DM with MASLD by Modulating Gut Microbiota and PPARγ","accession":"MTBLS13933","organisms":["Mus musculus"],"description":"
Type 2 diabetes mellitus (T2DM) with metabolic syndrome-associated steatohepatitis (MASLD) is a complex metabolic comorbidity characterized by hyperglycemia, pancreatic β-cell dysfunction, and hepatic lipid metabolism disorders, in which gut microbiota dysbiosis and abnormal PPARγ signaling play ","submission_date":"20260225"},{"title":"Cardiac untargeted lipidomics in cardiomyocyte-specific Srebp1a-Tg mice","accession":"MTBLS13690","organisms":["Mus musculus"],"description":"
Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider","submission_date":"20260115"},{"title":"Caridac untargeted lipidomics in Sham or TAC-operated mice pretreated with AAV9-NC or AAV9-cTnT-shSlc9a3","accession":"MTBLS13701","organisms":["Mus musculus"],"description":"
Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider","submission_date":"20260116"},{"title":"Cardiac untargeted lipidomics in cardiomyocyte-specific SREBP1 knockdown mice","accession":"MTBLS13696","organisms":["Mus musculus"],"description":"
Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider","submission_date":"20260115"},{"title":"Glycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes","accession":"MTBLS11411","organisms":["Homo sapiens"],"description":"Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris","submission_date":"20241220"},{"title":"RS5-lycopene complex alleviates diabetic glycogen fragility","accession":"MTBLS13849","organisms":["Mus musculus","Mus musculus"],"description":"
This study demonstrates for the first time that CS-LYC, an RS5-based starch-lycopene complex, alleviates T2DM via gut microbiota-mediated regulation, providing novel evidence supporting starch-based functional foods in T2DM management.
","submission_date":"20260205"},{"title":"Comparative 1H-NMR Lipoprotein Profiling of Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Highlights Disease-Specific Lipoprotein Dysregulation","accession":"MTBLS13820","organisms":["Homo sapiens"],"description":"Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are systemic autoimmune diseases associated with increased cardiovascular risk and metabolic alterations. We applied 1H-NMR spectroscopy to profile lipoproteins and metabolites in women with RA, SLE, and healthy controls. Both RA an","submission_date":"20260202"},{"title":"Comprehensive analysis of the microbiome and metabolome in pus from pyogenic liver abscess patients with and without diabetes mellitus","accession":"MTBLS7128","organisms":["Homo sapiens"],"description":"
Pyogenic liver abscess (PLA) patients combined with diabetes mellitus (DM) tend to have more severe clinical manifestations than without DM. The mechanism responsible for this phenomenon is not entirely clear. The current study therefore aimed to comprehensively analyze the microbiome composition","submission_date":"20230213"},{"title":"Insulin Resistance-Associated Bifidobacterium longum Ameliorates Prediabetes via the 6-ketoLCA/TGR5/GLP-1 axis","accession":"MTBLS13684","organisms":["Mus musculus","Mus musculus","Homo sapiens"],"description":"
Background Prediabetes, a global health concern characterized by insulin resistance (IR) and closely linked to obesity, was investigated in this study to identify key gut microbiota characteristics. The development of insulin resistance is associated with gut microbiota. Therefore, identifying ke","submission_date":"20260114"},{"title":"An integrated drug repositioning analysis for sarcopenia","accession":"MTBLS9582","organisms":["Mus musculus"],"description":"
Global population aging with increased longevity has incurred a higher prevalence of sarcopenia. Sarcopenia is characterized by age-related muscle/strength loss and is becoming a highly important public health issue. The development of sarcopenia increases the risk of various adverse health outco","submission_date":"20260109"},{"title":"Free fatty acid generation via Rhein-induced LDL-C endocytosis accelerates biofilm infected diabetic wound healing","accession":"MTBLS13603","organisms":["Homo sapiens"],"description":"
Diabetic foot infection (DFI) significantly increases risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) being key drivers of treatment failure. Here, we ana","submission_date":"20260105"},{"title":"Mechanism of Pediococcus acidilacticus YH-15 on Fat Reduction","accession":"MTBLS13595","organisms":["Rattus norvegicus","Rattus norvegicus"],"description":"
Obesity and related metabolic syndromes pose a growing global health challenge, increasingly linked to severe complications including cardiovascular disease, type 2 diabetes, and non-alcoholic fatty liver disease. High-fat diet (HFD) serves as a key environmental driver of obesity, disrupting gut","submission_date":"20260104"}]},"meta":{"timestamp":"2026-06-01T08:13:27.347Z","request_id":"7ff9180f-d21d-4792-85ee-d8333cd03891"},"status":"ok","message":"Search results retrieved","success":true}}}},"401":{"description":"Missing or invalid x-oanor-key header"},"402":{"description":"Active subscription required"},"429":{"description":"Rate-limit or monthly quota reached"},"502":{"description":"Upstream did not respond"}}}},"/v1/study":{"get":{"operationId":"get_v1_study","tags":["Studies"],"summary":"A study's full metadata","description":"","parameters":[{"name":"id","in":"query","required":true,"description":"MetaboLights accession, e.g. MTBLS1","schema":{"type":"string"},"example":"MTBLS1"}],"security":[{"oanorKey":[]}],"responses":{"200":{"description":"OK","content":{"application/json":{"example":{"data":{"study":{"title":"A metabolomic study of urinary changes in type 2 diabetes in human compared to the control group","assays":[{"platform":"Nuclear Magnetic Resonance (NMR) - - - Bruker","technology":"NMR spectroscopy assay","measurement":"untargeted analysis"}],"people":[{"name":"Reza M Salek","roles":["principal investigator role"],"affiliation":"University of Cambridge"},{"name":"Jules L Griffin","roles":["principal investigator role"],"affiliation":"University of Cambridge"}],"status":"Public","factors":["Gender","Metabolic syndrome"],"ftp_url":"http://ftp.ebi.ac.uk/pub/databases/metabolights/studies/public/MTBLS1","license":"EMBL-EBI Terms of Use","accession":"MTBLS1","submitters":["r7salek@gmail.com","jules.griffin@mrc-hnr.cam.ac.uk"],"description":"Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in this disorder and inadequate diagnostics. In this study, NMR-based metabolomic analysis in conjunction with uni- and multivariate statistics was applied to examine the urinary metabolic changes in Human type 2 diabetes mellitus patients compared to the control group. The human population were un medicated diabetic patients who have good daily dietary control over their blood glucose concentrations by following the guidelines on diet issued by the American Diabetes Association. Note: This is part of a larger study, please refer to the original paper below.","publications":[{"doi":"10.1152/physiolgenomics.00194.2006","title":"A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.","pubmed":"17190852","status":"published","authors":"Salek RM,Maguire ML,Bentley E,Rubtsov DV,Hough T,Cheeseman M,Nunez D,Sweatman BC,Haselden JN,Cox RD,Connor SC,Griffin JL"}],"sample_count":0,"last_modified":"2026-05-25T08:11:18.073044","protocol_count":7,"submission_date":"2012-02-14","design_descriptors":["diabetes mellitus","metabolic syndrome","Urine global profiling","nuclear magnetic resonance spectroscopy","Human Study Subject","untargeted metabolites"],"public_release_date":"2012-02-14"}},"meta":{"timestamp":"2026-06-01T08:13:27.530Z","request_id":"1e3249dd-8410-40e1-84fc-df338b7e65bd"},"status":"ok","message":"Study retrieved","success":true}}}},"401":{"description":"Missing or invalid x-oanor-key header"},"402":{"description":"Active subscription required"},"429":{"description":"Rate-limit or monthly quota reached"},"502":{"description":"Upstream did not respond"}}}},"/v1/organisms":{"get":{"operationId":"get_v1_organisms","tags":["Workflow"],"summary":"Organisms studied","description":"","parameters":[{"name":"id","in":"query","required":true,"description":"MetaboLights accession","schema":{"type":"string"},"example":"MTBLS1"}],"security":[{"oanorKey":[]}],"responses":{"200":{"description":"OK","content":{"application/json":{"example":{"data":{"count":1,"study":"MTBLS1","organisms":[{"organism":"Homo sapiens","organism_part":"urine","term_accession":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}]},"meta":{"timestamp":"2026-06-01T08:13:27.705Z","request_id":"dfb36041-51c7-4d0d-831b-993dbf92d753"},"status":"ok","message":"Organisms retrieved","success":true}}}},"401":{"description":"Missing or invalid x-oanor-key header"},"402":{"description":"Active subscription required"},"429":{"description":"Rate-limit or monthly quota reached"},"502":{"description":"Upstream did not respond"}}}},"/v1/protocols":{"get":{"operationId":"get_v1_protocols","tags":["Workflow"],"summary":"The analytical workflow","description":"","parameters":[{"name":"id","in":"query","required":true,"description":"MetaboLights accession","schema":{"type":"string"},"example":"MTBLS1"}],"security":[{"oanorKey":[]}],"responses":{"200":{"description":"OK","content":{"application/json":{"example":{"data":{"count":7,"study":"MTBLS1","protocols":[{"name":"Sample collection","type":"Sample collection","parameters":[],"description":"For the human studies, midstream urine (~15 ml) samples were collected and frozen from each volunteer. In total, 84 samples were collected from 12 healthy volunteers (7 time points, 8 males and 4 females) and 50 samples from 30 T2DM patients (1-3 time points, 17 males and 13 females) with well-controlled blood glucose maintained at normal concentrations by diet, following the guidelines issued by the American Diabetes Association, rather than medication. T2DM patients agreed to stop treatment with oral anti-diabetic agents during the study. Subjects went through a washout period of 4 wk before sample collection and abstained from alcohol during the study; diet was controlled throughout the study."},{"name":"Extraction","type":"Extraction","parameters":["Extraction Method"],"description":"For the human studies, midstream urine (∼15 ml) samples were collected and frozen from each volunteer. In total, 84 samples were collected from 12 healthy volunteers (7 time points, 8 males and 4 females) and 50 samples from 30 T2DM patients (1–3 time points, 17 males and 13 females) with well-controlled blood glucose maintained at normal concentrations by diet, following the guidelines issued by the American Diabetes Association, rather than medication. The healthy subjects were aged 18–55 yr, had a body mass index (BMI) ≥19 and ≤30 kg/m2 and a body mass ≥50 kg and ≤113 kg, and were free from any major disease or pregnancy. The T2DM patients were aged 30–65 yr (mean 56 ± 9 yr), had a BMI >25 and <40 kg/m2, weighed between 65 and 140 kg (mean 95 ± 19 kg), and were taking at most one oral anti-diabetic drug. T2DM patients agreed to stop treatment with oral anti-diabetic agents during the study. Subjects went through a washout period of 4 wk before sample collection and abstained from alcohol during the study; diet was controlled throughout the study."},{"name":"NMR sample","type":"NMR sample","parameters":["NMR tube type","Solvent","Sample pH","Temperature"],"description":"Aliquots of 400 µl urine samples were made up to 600 µl with phosphate buffer (0.2 M, pH 7.4) and any precipitate removed by centrifugation. In total, 500 µl of supernatant were transferred to 5-mm NMR tubes with 100 µl of sodium 3-trimethylsilyl-(2,2,3,3-2H4)-1-propionate (TSP)/D2O/sodium azide solution (0.05% wt/vol TSP in D2O and 1% wt/vol sodium azide)."},{"name":"NMR spectroscopy","type":"NMR spectroscopy","parameters":["Instrument","NMR Probe","Number of transients","Pulse sequence name","Magnetic field strength"],"description":"The spectra of human urine samples were acquired on a Bruker DRX700 NMR spectrometer using a 5 mm TXI ATMA probe at a proton frequency of 700.1 MHz and ambient temperature of 27 °C."},{"name":"NMR assay","type":"NMR assay","parameters":[],"description":"A 1D NOESY presaturation pulse sequence was used to analyze the urine samples. For each sample 128 transients were collected into 64k data points using a spectral width of 14.005 kHz (20 ppm) and an acquisition time of 2.34 s per FID."},{"name":"Data transformation","type":"data transformation","parameters":[],"description":"Spectra were processed using ACD/1D NMR Manager 8.0 with Intelligent Bucketing Integration (Advanced Chemistry Development, Toronto, ON, Canada). Spectra were integrated 0.20-9.30 ppm excluding water (4.24-5.04 ppm), glucose (3.19-3.99 ppm, 5.21-5.27 ppm), and urea (5.04-6.00 ppm). Intelligent bucketing ensures that bucket edges do not coincide with peak maxima, preventing resonances from being split across separate integral regions; a 0.04 ppm bucket width and a 50% looseness factor were used. All spectra were normalized to total area excluding the water, urea, and glucose regions."},{"name":"Metabolite identification","type":"metabolite identification","parameters":[],"description":"Assignments were confirmed by two dimensional spectroscopy including homonuclear 1H-1H Correlation Spectroscopy (COSY), 1H-13C Heteronuclear Signal Quantum Coherence (HSQC) and 1H-13C Heteronuclear Multiple Bond Correlation (HMBC) Spectroscopy."}]},"meta":{"timestamp":"2026-06-01T08:13:27.929Z","request_id":"0203948c-28cb-4a77-bf24-e47895d9d079"},"status":"ok","message":"Protocols retrieved","success":true}}}},"401":{"description":"Missing or invalid x-oanor-key header"},"402":{"description":"Active subscription required"},"429":{"description":"Rate-limit or monthly quota reached"},"502":{"description":"Upstream did not respond"}}}},"/v1/meta":{"get":{"operationId":"get_v1_meta","tags":["Meta"],"summary":"Usage notes","description":"","parameters":[],"security":[{"oanorKey":[]}],"responses":{"200":{"description":"OK","content":{"application/json":{"example":{"data":{"note":"Open metabolomics studies archive. MetaboLights is the world's premier repository for metabolomics experiments (NMR & mass-spectrometry), a sister resource to PRIDE (proteomics). /v1/search?query=diabetes = search public studies (accession, title, description, organism, study type); /v1/study?id=MTBLS1 = a study's full metadata (title, abstract, status, submission & release dates, study-design descriptors, experimental factors, analytical assays with measurement & technology type and platform, contributors and roles, linked publications with DOI/PubMed, submitters, sample count, FTP download URL, data license); /v1/protocols?id=MTBLS1 = the analytical workflow — each protocol's name, type, description and parameters (sample collection, extraction, chromatography, NMR/MS spectroscopy, data transformation, metabolite identification); /v1/organisms?id=MTBLS1 = the organisms and organism parts studied with their ontology term. Study accessions look like MTBLS1. Data from EMBL-EBI MetaboLights. 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