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API · /ena-api

ENA API

healthy 4,897 Subscribers

The European Nucleotide Archive (ENA) as an API, powered by EMBL-EBI — one of the three INSDC partners alongside NCBI GenBank and DDBJ, and the comprehensive public archive of the world's nucleotide sequence data. ENA holds raw sequencing reads, assembled and annotated genomes, individual sequences, biological samples and the studies behind them, for every domain of life — the backbone resource for genomics, microbiology, ecology, evolution and clinical research. This API gives a clean three-step workflow over that archive. First, /v1/taxon resolves an organism name (e.g. "Homo sapiens") to its NCBI taxon id, scientific name, taxonomic rank and full lineage — or looks a taxon up directly by id. Then /v1/search queries the archive for that taxon's records of a chosen type: genome assemblies (with assembly name, level and base count), sequencing runs (with platform, instrument and read counts), biological samples (with collection date and country), annotated sequences, read experiments, analyses, coding and non-coding sequences, and studies — by default including all descendant taxa, or restricted to the exact taxon. Finally /v1/record returns a summary for any ENA accession — assemblies (GCA_…), studies and projects (PRJ…), samples (SAM…/ERS…), sequencing runs (ERR…/SRR…) and sequences — with its title, data type, taxon, scientific name, base and sequence counts and public status. Ideal for bioinformatics pipelines, genome-data discovery, sequencing-metadata harvesting, biodiversity and metagenomics tooling, and research reproducibility. Taxon ids look like 9606 (human); accessions like GCA_000001405. Data from EMBL-EBI ENA, an INSDC archive, free to use.

#ena #nucleotide #genomics #sequencing #bioinformatics #embl-ebi #insdc #life-sciences
api.oanor.com/ena-api
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Machine-readable spec so AI agents can integrate this API.

/api/ena-api/openapi.json
/api/ena-api/llms.txt

Discovery: GET /api/index.json lists every API.

API health

healthy
Uptime
100.00%
Server probes · 24h
Avg latency
155 ms
Server probes · 24h
Subscribers
4,897
active
Total calls
8
last 7 days
status Full status page → · 12 probes/24h

Pricing

Pick a tier — billed monthly, cancel anytime.

Free

Free

  • 600 calls / month
  • 2 requests / second
  • Hard cap (429 above quota, no overage)
  • 600 calls/month
  • 2 req/sec
  • Taxon resolve, search & records
  • No credit card
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Starter

€9.00 /month

  • 24,000 calls / month
  • 5 requests / second
  • Hard cap (429 above quota, no overage)
  • 24k calls/month
  • 5 req/sec
  • All record types
  • Email support
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Pro

€27.00 /month

  • 115,000 calls / month
  • 12 requests / second
  • Hard cap (429 above quota, no overage)
  • 115k calls/month
  • 12 req/sec
  • Pipeline & metadata harvesting
  • Priority support
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Mega

€69.00 /month

  • 470,000 calls / month
  • 35 requests / second
  • Hard cap (429 above quota, no overage)
  • 470k calls/month
  • 35 req/sec
  • High-throughput genomics
  • Dedicated SLA
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Related APIs

Other APIs with overlapping tags.

Genome Assemblies API

Reference genome assemblies as an API — powered by NCBI Assembly, the registry of genome builds for organisms across the tree of life. Search assemblies by organism (or free text) and look up any assembly's metadata: its accession (GCF_… RefSeq or GCA_… GenBank), name (e.g. GRCh38.p14), organism and taxon id, assembly level (complete genome, chromosome, scaffold or contig), contiguity statistics (contig and scaffold N50), sequencing coverage, RefSeq category, UCSC and Ensembl names, the submitting organization, release date and FTP download paths. From the human reference genome to any sequenced microbe, plant or animal, it turns the genome-assembly registry into a clean search-and-fetch API. A genome-assembly registry — distinct from sequence (ENA), genome annotation (Ensembl), variant (ClinVar, dbVar) and gene-expression (GEO) databases. Open data from NCBI Assembly (public domain).

api.oanor.com/genomes-api

Gene Expression API

Functional-genomics experiments as an API — powered by NCBI GEO (Gene Expression Omnibus), the largest public repository of gene-expression data. GEO archives expression series and curated datasets from microarray and high-throughput-sequencing experiments across every organism. Search experiments by keyword and optionally by organism, and look up any series or dataset to get its metadata: title, summary, assay type (expression profiling by array or by sequencing), organism, number of samples, platform and the publication behind it. From β-cell stress studies to cancer transcriptomics across human and mouse, it turns the GEO archive into a simple search-and-fetch API for transcriptomics, bioinformatics and research-data discovery. A gene-expression / functional-genomics dataset repository — distinct from sequence (ENA), variant (ClinVar, dbVar), structure (PDB) and ontology databases. Open data from NCBI GEO (public domain).

api.oanor.com/geodatasets-api

Structural Variants API

Human genomic structural variation as an API — powered by NCBI dbVar, the archive of structural variants (SVs): copy-number variants (CNVs), large deletions, duplications, insertions, inversions and translocations, typically larger than 50 base pairs. This is the structural counterpart to single-nucleotide variant databases: search structural variants overlapping a gene (or by free text) and get each variant's dbVar accession, the study it came from, its type, the genes it overlaps, its genomic placement on GRCh38 and its clinical significance; then look up any variant for the full record — placements on both GRCh37 and GRCh38 assemblies, variant type, genes, clinical significance, study type, methods and variant counts. From BRCA1 CNVs to Cri-du-chat deletions, it is ideal for genomics, cytogenetics, rare-disease and bioinformatics work. A structural-variation / CNV resource — distinct from clinical single-nucleotide variant interpretation (ClinVar), population allele frequencies (gnomAD) and trait associations (GWAS). Open data from NCBI dbVar (public domain).

api.oanor.com/dbvar-api

Protein Interactions API

Protein-protein interaction networks as an API — powered by STRING, the database of known and predicted protein associations that combines evidence from laboratory experiments, curated pathway databases, gene co-expression, genomic context and automated text mining into a single confidence score, across thousands of organisms. Get a protein's top interaction partners (each with the combined confidence score and the seven evidence-channel subscores), the interaction network among any set of proteins as scored edges, and functional enrichment for a gene set — the over-represented GO terms, KEGG pathways, Pfam domains and more, each with its p-value, FDR and member genes. Pass gene symbols (TP53) or STRING/Ensembl ids, for human (default) or any species by NCBI taxon id. It is a cornerstone of systems biology — ideal for network analysis, functional genomics, pathway and bioinformatics tools. A protein-interaction-network resource — distinct from biological pathways (Reactome), curated protein complexes (Complex Portal) and Gene Ontology annotations (QuickGO). Open data from STRING (CC BY 4.0).

api.oanor.com/stringdb-api

Frequently asked questions

Quick answers about pricing, quotas, and integration.

How do I get an API key for ENA API?
Sign up for free at oanor.com, generate an API key from the developer dashboard, and call ENA API with the x-oanor-key header. No credit card needed for the free tier.
What's the rate limit for ENA API?
Free tier allows 1 request per second. Paid plans scale up to 50 requests per second on the Mega tier. Hard limits return HTTP 429 above the quota — no surprise overage charges.
How much does ENA API cost?
ENA API has a free tier with 100 calls / month. Paid plans start at €9.00 / month with higher quotas and faster rate limits.
Can I cancel my subscription anytime?
Yes. Plans are billed monthly and you can cancel anytime from your billing dashboard. No long-term contracts and no cancellation fee.
Is ENA API GDPR-compliant?
All requests to ENA API go through our EU-based gateway. Your upstream API key never leaves our server and no personal data is shared with the upstream provider beyond the request you send.

Pick an endpoint from the list on the left to see its details and try it.

Code snippets

Sign up to get an API key, then call any path under your slug.

curl https://api.oanor.com/ena-api/SOME_PATH \
  -H "x-oanor-key: oanor_test_..."
const res = await fetch("https://api.oanor.com/ena-api/SOME_PATH", {
  headers: { "x-oanor-key": "oanor_test_..." }
});
const data = await res.json();
$ch = curl_init("https://api.oanor.com/ena-api/SOME_PATH");
curl_setopt($ch, CURLOPT_RETURNTRANSFER, true);
curl_setopt($ch, CURLOPT_HTTPHEADER, ["x-oanor-key: oanor_test_..."]);
$response = curl_exec($ch);
import requests
r = requests.get(
    "https://api.oanor.com/ena-api/SOME_PATH",
    headers={"x-oanor-key": "oanor_test_..."},
)
print(r.json())

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